Biology · BIOMOLECULES

The inhibition of succinic dehydrogenase by malonate is a classic example of competitive inhibition. Which of the following statements explains why this inhibition is competitive?

1. Malonate binds covalently to an allosteric site causing permanent distortion of the catalytic domain.
2. Malonate cleaves the peptide backbone of succinic dehydrogenase through hydrolytic action.
3. Malonate chemically oxidises succinate before it can encounter the active site.
4. Malonate closely resembles the substrate succinate in molecular structure and competes for the enzyme's substrate-binding site.